Male | 67
Am I Dealing with Polycythemia Vera or Secondary Cause?
Dear Doctor, Due to my father's high blood viscosity, suspicion of polycythemia arises, necessitating blood draws every 3 weeks to maintain appropriate levels. At 69 years old, he experiences symptoms such as skin itching, swelling, head numbness, and fatigue. Currently, his JAK2 V617F mutation showed 0.8 then 1.2%, with JAK2 exon 12 negative and EPO at 13.4. Abdominal CT and chest X-ray are normal. After a few months of phlebotomy, his levels normalized. Now, we await the bone marrow biopsy results, which do not confirm Polycythemia Vera: "Microscopic description: The bone marrow biopsy sample shows somewhat hypocellular hematopoietic parenchyma relative to age, which is terminally mature. Myeloid ratio is 2:1 with dominance of late precursors; no blast cells are noted. The number of megakaryocytes is normal with no clustering. There is no interstitial fibrosis or lymphoid infiltrate. Diagnosis: Mature, hypocellular hematopoietic parenchyma without myeloproliferative features. Cytogenetic analysis confirmed male karyotype; no clonal chromosomal abnormalities detected. Indication for examination D7510 Secondary polycythemia Note Submicroscopic rearrangements, small structural chromosomal aberrations, DNA-level differences cannot be ruled out with the method used." I am quite confused as JAK2 positivity typically suggests PV, yet the biopsy suggests otherwise, possibly indicating secondary polycythemia. Could you please clarify based on this information what you personally think is more likely, Polycythemia Vera or another secondary cause? Thank you very much for your help.

General Physician
Answered on 3rd July '24
Your father's symptoms and test results do suggest some complexity. The presence of JAK2 mutation often points towards Polycythemia Vera (PV), but the bone marrow biopsy does not show typical myeloproliferative features, suggesting it might be secondary polycythemia instead. Consult a hematologist, specializing in blood disorders, and can provide a more accurate diagnosis and appropriate treatment plan.
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Questions & Answers on "Hematology" (255)
Good day doc, I noticed some traces of blood in my mucur. What could be the possible cause and solution
Male | 29
When you find some blood in mucus, it can indicate several ailments. Possible reasons could be a nosebleed, irritation by dry air, or an infection such as sinusitis. If you are facing a runny nose, pain in your face, or a sore throat, that could be a sign of an infection. Drinking a lot of water, using a humidifier, and visiting a doctor if it persists are the ways to go.
Answered on 18th Sept '24
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My brother had cbc and esr and he was diagnosed with Normocytic, normochromic. Leucocytosis. Kindly guide what is this issue n what should he do
Male | 35
Normocytic, normochromic. Leucocytosis refers to the fact that your brother's red blood cells are of normal size and with normal coloration, but he has too many white blood cells. This can be caused by infection, inflammation, or stress. Another common symptom would be fatigue, fever, and body aches. Treatment will depend on the underlying cause, so it's important to consult a hematologist for further evaluation and appropriate management.
Answered on 27th Nov '24
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Is 3.5 mmol/l cholesterol is normal
Male | 37
When you have 3.5 mmol/l cholesterol, that is okay. Cholesterol is like fat in your blood. If your cholesterol is high, there are usually no signs. An unhealthy diet, not doing enough exercise, and a family history can cause this condition. To stay healthy with it being normal eat well and exercise regularly also if necessary take some drugs from the doctor.
Answered on 6th June '24
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Dear Madam/Sir My Mother aged 59 years old is having Hernia of 2mm.. Doctor recommended for surgery but WBC Count is 16000+. How to control WBC & to Control WBC Which test is recommended?
Female | 59
Your mom's high white blood cell count shows there could be an infection. After her hernia surgery, you'll want to tackle that. Doctors usually suggest a blood culture test to pinpoint the infection source. High WBC can bring fever, fatigue, and discomfort. Treating the infection should lower her WBC count. Make certain she finishes all her antibiotics as prescribed to help get that WBC in check before her procedure.
Answered on 11th Sept '24
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My uric acid test report 5.9 please tell me ok not ok
Male | 29
The uric acid level of 5.9 is already above normal. It might remain asymptomatic at first, yet if untreated, it may lead to gout, which is characterized by pain and swelling in the joints. Your uric acid level can be decreased by drinking more water, avoiding alcohol, and less red meat and seafood. Besides this method, exercising regularly may also be beneficial.
Answered on 20th Aug '24
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My patlet -154000 MPV -14.2 Is it ok
Male | 39
A platelet count below 150,000 is considered low. Platelets help the blood clot properly. Low levels can cause bruising easily, bleeding, or tiny red spots called petechiae. An MPV of 14.2 is slightly below normal too. This could happen due to infections, medications, or medical issues. It's crucial to talk to your doctor about these results. They'll check further and recommend the right treatment.
Answered on 5th Sept '24
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Vit b12 very low less than 100 Hscrp very high 20.99( taken at the time of menstruation) Hb slightly low 11.6 Bun creatinine slightly low Iron was very low 34.46 AVG bld glucose slightly low 88
Female | 19
It looks like there are certain elements that are below the required levels in your body. For it to function properly, your body needs them. Feeling tired, weak, or unlike yourself can be signs of insufficient amounts of these substances. When some substances are too many, then it may mean that the body is fighting something. To help you feel better soon, you might have to take such supplements like Vitamin B12 or Iron among others.
Answered on 27th May '24
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I am 16 years old I am suffering from sickle cell I currently have pain all over my body please help me
Female | 16
Sickle cell is a condition where your red blood cells are of the wrong shape that can easily block the blood flow of the blood and thus become painful. This phenomenon occurs in every part of the body. It can lead to fatigue as well. To heal, you are recommended to take warm baths, drink water, and rest. You should also talk to your doctor for more help.
Answered on 9th Sept '24
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I am loosing weight continuously and getting slim like anaemia patients skin is so dull and sagging and I feel dizzy sometimes, get tired easily can't sit longer because my blood cells stops working so I have to move every moment
Female | 23
Anemia results from a deficient number of healthy red blood cells in the bloodstream. Low red blood cells mean asthma, dizziness, and quick weight loss. Your skin can also become pale and saggy. More spreadsheets with foods high in iron such as spinach and beans are advisable. Your doctor can also give you iron pills to increase the number of red blood cells.
Answered on 4th Sept '24
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Today morning toilet time red blood coming which problem name what is solved sir/Medam
Male | 31
If you saw red blood when you went to the toilet this morning, it might be due to hemorrhoids. These are engorged blood veins in the rectum or anus. Such signs are as follows: bloody stool, pain around the anus, and itching. It is suggested to increase water intake, include fiber in your diet, and avoid lifting heavy things during bowel movements.. In case the bleeding still occurs or if you have extreme pain, it is necessary to make an appointment with a gastroenterologist to diagnose the causes and find the proper treatment.
Answered on 22nd July '24
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Typhoid IgM antibody Weak positive means..??
Female | 21
Typhoid IgM antibody denotes your system battles a nasty bug, typhoid fever. High temprature, fatigue, tummy hurt, head pain. Test helps spot early. Hydrate well. Take antibiotics. Rest up. Follow doctor's orders.
Answered on 25th July '24
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I have test today wbc is 12800 And neut 42, lymph 45
Male | Jay
A white blood cell count at 12,800 with neutrophils at 42% and lymphocytes at 45% indicates the possibility of an infection. The symptoms may be such as the fever, the fatigue, and body aches. The reasons can be a bacterial or viral infection. Stay home, drink fluids, and eat well. If the symptoms are getting worse or not disappearing, you have to see a doctor immediately.
Answered on 21st Oct '24
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My wife is suffering with low hemoglobin, RBC , WBC & patlets count gone on decreasing .She has sufferd with viral fever for 15 days, viral fever came to normal but counts were not increasing.she has treated 20 days in KIMS, hyderabad hospital. Kims doctors told that after few days gradually counts will increase. What is her problem upto now doctors did not diagnosis, Two or three days doctors are transmitting sdp and prbc and WBC injections.I'm taken second opinion he told that there is a problem in bone marrow.without daignoses if we take bone marrow treatment does patient get any side effects.she is suffering from legs pain and swalling in legs aslo and she is becoming weak. Please what is her problem give me the clarity
Female | 36
Answered on 23rd May '24
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We have done test of asylum serum and it is increased in reports at 142. Is it something to worry about
Male | 44
You had a high result for asylum serum, at 142. This could signal an issue with your liver or bones. Feeling tired, losing weight, or belly pain, are possible symptoms. Causes: liver problems, or bone troubles. It's wise to see a doctor to find out what's happening. They can determine the right treatment.
Answered on 23rd July '24
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Period blood is black wh?
Female | 23
Dark or black menstrual flow can occur as a result of blood that has taken longer to exit the uterus, often indicating older blood. This can happen during lighter periods or at the beginning or end of your cycle. Factors such as hormonal changes, stress, and various health conditions can also influence flow color. Generally, there's no cause for alarm. However, if you experience unusual symptoms like severe pain or significant changes in your pattern, a consultation with a gynecologist is advisable to ensure everything is well.
Answered on 30th Jan '25
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I'm 30 years old , my hb level increases to 16.3 ,what should I do now to reduce that to normal, will it cause any serious issues, please suggest me
Female | 30
A hemoglobin level of 16.3 g/dL is slightly above the average range. While often not concerning, it’s essential to consider potential symptoms like fatigue or dizziness. High levels could arise from dehydration, smoking, or living at high altitudes. To normalize your hemoglobin, ensure adequate hydration, maintain a balanced diet, and avoid tobacco. Engaging in regular exercise can also help. However, it’s advisable to consult an endocrinologist for personalized guidance and evaluation, as they can determine underlying causes and recommend appropriate actions.
Answered on 20th Feb '25
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I finished taking pep on 16th this month on 18th I started experience flu headache,fatigue stuffy and runny nose,sore throat,but today the sorethroat has vanished but I have mouth ulcers at my lips.what would it be am worried
Male | 27
The flu-like signs you experienced, such as headaches and fatigue, can be common after starting medication like PEP, as your body adjusts. Mouth ulcers may arise from factors like stress, dehydration, or irritation. Staying well-hydrated and practicing good oral hygiene can help soothe these sores. If the discomfort persists or worsens, I recommend consulting a physician for personalized advice and to ensure everything is progressing well.
Answered on 24th Feb '25
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I have 16 pea sized lymph nodes I am 57kg my height is 5ft 10 I’ve had them for almost 2 years and they haven’t got bigger or changed I’ve had blood tests previously and they all came back fine. I do have 2 under my jaw that’s a bit bigger than a pea though. Is it a concern? I have no symptoms except bad anxiety. I am highly afraid of cancers
Male | 17
Your lymph nodes not changing size or growing for two years is good. When it comes to cancer we tend to worry a lot due to anxiety. They might remain slightly enlarged sometimes. It’s usually benign but it would be prudent to get the larger ones checked by your doctor. Additionally, work on calming down your nerves because that can also be of help.
Answered on 13th Dec '24
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I would like to have my blood test result be explained to me. Thank you
Female | 60
One of the crucial parts of your well-being is your capability to interpret blood analyses. Usually, these outcomes are the source of several pieces of information, among them vitamin amounts, the equilibrium of hormones, as well as signs of inflammation and infection. Disorders like chronic discomfort, tiredness, and weakness can be regarded as typical consequences of a certain hormonal imbalance. Discrepancies, on the other hand, might come from a wide range of reasons including poor nutrient intake through cardiology to some internal blockage. It’s the duty of the doctor to enumerate the results which patients require to be aware of and to advise them according to their particular situation.
Answered on 16th Dec '24
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Platelet count noly. 5000
Male | 9
A platelet count of 5000 is very low. Platelets are small UCS in your blood that support the process of transporting blood to your body. When your count is low you could experience symptoms such as easy bleeding, a lot of bruises, or have nosebleeds. Low platelets can be a side effect of several medicines, infections, or diseases. To tackle the problem, doctors may either prescribe medication or transfuse safe platelets.
Answered on 11th Sept '24
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