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Male | 60

Could Diuretics be Impacting My GFR Levels?

Hello (apologies for long post) Caucasian, Male, 60, 6'0", 260 lbs. Meds: Lisinopril 40 mg, Metoprolol 50 mg x2 a day, Amlodipine 10 mg, Furosemide 20 mg, Glimepiride 1 mg, Janumet 50-1000 x 2, Atorvastatin 10 mg...NO drink/smoke or rec. drugs. Issue: After a lot of work, have lost 40+ lbs in last 5-6 years...blood pressure 130/85, A1c 7.0 ...here is the issue. In March of 2023, after years of my GFR staying constant in mid/upper 40's, (not great, but consistent), it was lower at 41. Dr wanted to check it again in 1 month. I very strictly controlled my diet/sugar/protein/soda/increase water intake, etc...take meds religiously...GFR dropped to 35. Dr sent me to a nephrologist, but before the scheduled appointment (which was 6 weeks later), he took me off of Triamterene...said it can be hard on kidneys. When the nephrologist sent me for labs, GFR went UP to 50. Another test 2 weeks later and GFR went up to 55. Nephrologist says that removing Triamterene from regimen played NO part in GFR rising...put me on Spironolactone due to edema returning . 6 months later at next check-up, all numbers and BP continue to be good, but GFR back down to 40. Is it possible that the diuretics have been hard on my kidneys and causing the lower GFR. I understand with years of HBP/diabetes, the GFR is not ideal, but I'd like to keep it in the 50's if possible. Family doctor took me off the Spironolactone and put me on Lasix in March of 2024...bloodwork coming up in a couple of weeks. Family doctor seems to think the diuretics have contributed to lower GFR...Nephrologist says they have nothing to do with my fluctuating GFR numbers... seeking input from anyone here with knowledge/experience...appreciate any insights re: affect of diuretics on GFR...alternatives to traditional diuretics, etc. I've read loop diuretics like Lasix best for kidney issues.

1 Answer

Answered on 22nd Aug '24

Diuretics such as Triamterene may have been responsible for your kidney problems, which in turn may have resulted in the increase or decrease of your GFR. The switch from you to Lasix by your family doctor is a good decision as it is a diuretic that may be less harsh on the kidneys. Continue to collaborate with a nephrologist to discover the optimal treatment for you.

2 people found this helpful

Questions & Answers on "Nephrologyy" (81)

Cardiac or diabetes and issues is proteinurea

Male | 67

If someone is having problems with their heart or diabetes and is also having protein in their urine, this may mean there could be damage to the kidneys. The signs of this illness are the puffiness of the body, the appearance of bubble-like urine, and the presence of hypertension. This can be caused by increased sugar levels or high blood pressure in the blood. Eat healthy, control your blood sugar, and take medication as directed.

Answered on 26th June '24

Dr. Babita Goel

Dr. Babita Goel

Şu anda 20 yaşındayım yeni biyopsi oldum sonucuma bakarmısınızIKLAMA: 7yaşında nefrotik sendrom tanısı alan ve tedavi gören olgu, albumin düşüklüğü sebebi ile biyopsi alınma kliniği bildirilen olguya ait HE detayda, 20 adet glomerül izlenmiş olup, 2 glomerülde global skleroz izlenmiştir. Diğer glomerüller irili ufaklı çaplarda olup, Bowman aralıkları açık olarak gözlendi. Glomerüler bazal membranlarda hafif kalınlaşma bazı glomerüllerde mevcuttu. Ancak tüm glomerüllerde mezengial hücre artışı-matriks artışı gibi bulgular izlenmedi. Glomerüler alanda izlenen bulgular spesifik olarak izlenmezken,interstisyel damarlardan (orta çaplı damarlarda) bir tanesinde duvar kalınlaşması, lümen daralması gibi vasküler basınç değişiklikleri lehine yorumlanabilecek bulgular izlenmiştir. Detayda ilave olarak interstisyel fibrozis (%20-25) iken; interstisyel alanda köpüksü histiositler ve lenfoplazmositlerin de eşlik ettiği ksantogranülomatöz pyelonefrit morfolojisi izlendi.Tubuler alanda patoloji izlenmedi. Sayfa 1\ 2

Dişi | 20

Answered on 12th Aug '24

Dr. Babita Goel

Dr. Babita Goel

I am 66 years old. Known case of ESRD on heamodialysis 3 times for the last 5 months. H/O htn on medication for the last 9ys . No DM . Past HO hepatitis c ( cured)

Male | 66

When you have ESRD, your kidneys do not work well. Although dialysis is working for you, high blood pressure may cause more difficulties. Be on the lookout for signs like being tired, swollen body parts and/or having trouble breathing. Do not stop taking your hypertension drugs; also follow a diet that is good for the kidneys plus keep being active. 

Answered on 30th May '24

Dr. Babita Goel

Dr. Babita Goel

I have started having sharp pain in right back side so I go to the doctor and I did sonography and my sonography showed 7mm kidney stone at right kidney in upper calayx and irregular urinary bladder wall? cystitis pvr 5cc noted then doctor give me medicine I took tablets 15 days and now after two months Vomiting once and fever at night and back pain on right side and little burning urine and weakness and I go to the bams doctor and he give me calcury tab 2tab two time a day for 10 days but this time no fever or vomate only sometime right back pain and sometime burning urine. Do I go back to the Calcuri tab at the same dose?

Male | 21

Your symptoms of back pain, urine burning, and general weakness are likely due to the kidney stone. I suggest you to keep on taking Calcury tablets as the BAMS doctor prescribed you. Stay well-hydrated and eat a balanced diet. If these symptoms last or worsen, it's vital to get medical help. 

Answered on 22nd Aug '24

Dr. Babita Goel

Dr. Babita Goel

My son suffering from dm 1 ,now ckd ,what may be solution

Male | 25

Diabetes type­ 1 and chronic kidney disease make­ a challenging combo. Kidneys can get damage­d by diabetes over time­. Look out for fatigue, swelling, and urinary troubles - the­se signal kidney problems. Controlling blood sugar le­vels and blood pressure he­lps protect the kidneys. Eating right and regular doctor visits matte­r a lot.

Answered on 23rd July '24

Dr. Babita Goel

Dr. Babita Goel

My wife is 39 years old suffering from CKD.Her cretanine pevel is 6.4

Female | 39

Your wife is likely to be getting symptoms such as fatigue, swelling, and trouble breathing if the creatinine level is 6.4. This could be from Chronic Kidney Disease (CKD), which is when the kidneys get damaged. To help manage this, she needs to follow a low-salt diet, take the prescribed medications, and possibly undergo dialysis. It's vital to ensure that her condition is stable by doing regular check-ups.

Answered on 3rd Sept '24

Dr. Babita Goel

Dr. Babita Goel

I describe below our patient problem: 1. Suggestive of left renal mass with thrombus in left vein. 2. left paraaortic lymphadenopathy. 3. Visible part of chest shows multiple soft tissue nodules in basal segments of both lung, largest one - 3.2X 2.8 cm - suggest metastasis.

Female | 36

send reports initially

Answered on 10th July '24

Dr. N S S Gauri

Dr. N S S Gauri

Patient have kidney stone ,when daily consumption of 1.5gram turmeric power with 1 glass water is healthy or unhealthy for kidney stones patient and patient also have fatty liver

Male | 65

Herbal Home Treatment for Kidney Stones and Fatty Liver One of the most surprising health benefits attributed to turmeric is the treatment of kidney stones and fatty liver. Turmeric has a compound curcumin which may assist in the disbanding of kidney stones and also reduce inflammation in the liver. However, always, it is your doctor who decides whether you can start a new treatment or not. Also, don't forget to drink more water so the stones will be easily removed. 

Answered on 13th Sept '24

Dr. Babita Goel

Dr. Babita Goel

Kidney and creatine level problem?

Male | 53

Kidneys filte­r waste from blood. If creatinine le­vels rise, kidneys struggle­. Tiredness, swelling, and nause­a occur. Causes include hyperte­nsion, diabetes, certain me­dications. Doctors prescribe medicine­, diet changes, sometime­s dialysis. Following medical advice prese­rves kidney function.

Answered on 2nd Aug '24

Dr. Babita Goel

Dr. Babita Goel

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