Phenylephrine can raise your blood pressure and it might be unsafe for the heart if one is on atenolol already. In case you have no idea, you can use other treatments for piles that lack this drug like say witch hazel pads alternatively try out nonprescription hydrocortisone creams too. With these substitutes in mind, there won’t be any need to worry about a thing because they will still help soothe them but without affecting or changing anything about how well the medicine works for your heart condition. Nevertheless, should there still be no relief from piles after using these methods then I would advise that you talk with a healthcare professional.