Understanding Mildly Elevated AST, ALT, and Globulin Levels

• Cirrhosis is a late stage of liver scarring (fibrosis) induced by a variety of liver disorders and conditions, including hepatitis and persistent drinking. When your liver is damaged, whether through illness, excessive alcohol intake, or another cause, it attempts to restore itself. Scar tissue arises as a result of the procedure.

• It causes scar tissue to grow, making it harder for the liver to function (decompensated cirrhosis) and is considered to be potentially fatal by nature. The liver damage is often irreversible. However, if detected early and the underlying cause is addressed, additional damage can be reduced and, in rare cases, reversed.

• It often has no signs or symptoms until liver damage is extensive.

• On damage the following signs/symptoms can be seen  - Fatigue , easy bleeding/bruising , Loss of appetite, Nausea, pedal/ankle odema, Weight loss, Itchy skin, Yellow coloured eyes and skin, ascites(fluid accumulation in abdomen), spiderlike blood vessels, redness of palms, absence/loss of periods (not related to menopause), libido and gynecomastia(breast growth in males)/testicular atrophy, Confusion, sleepiness, and slurred speech (hepatic encephalopathy)

• Usually, the total bilirubin test shows 1.2 mg/dL for adults and 1 mg/dL for children under the age of 18. The normal value for direct bilirubin is 0.3 mg/dL.

• Normal findings may differ somewhat between men and women, and results may be influenced by particular diets, drugs, or severe activity. Bilirubin levels that are lower than normal are typically not a cause for worry. Elevated levels might be a sign of liver injury or illness.

• Higher-than-normal amounts of direct bilirubin in your blood may suggest that your liver isn't adequately removing bilirubin. Elevated indirect bilirubin levels may signal other issues.

• Gilbert's syndrome, a lack in an enzyme that aids in the breakdown of bilirubin, is a frequent and innocuous cause of high bilirubin. Further tests may be ordered by your doctor to explore your situation. Bilirubin test results can also be used to track the evolution of specific illnesses like jaundice.

• Further laboratory investigations such as AST(aspartate aminotransferase), ALT(alanine transaminase), ALP(alkaline phosphatase) and GGT(gamma-glutamyl transpeptidase); Total Albumin, Lactic Dehydrogenase, Alpha protein, 5’nucleotide, mitochondrial antibody and PTT levels need to be determined and procedures such as CT scan, MRI (for liver tissue damage) and biopsy (in case of chance of any cancerous growth) need to be performed.