The gastrointestinal tract is the most common site of extranodal involvement for diffuse large B-cell lymphoma (DLBCL),but there is deficit of enough study in such cases therefore the best combination of treatment is subject of discussion. Currently, a combination of surgery followed chemotherapy is considered primarily because the preoperative diagnosis is difficult and risk of complications requiring surgery is quite high during chemotherapy. As per studies surgery plus chemotherapy was associated with a lower rate of relapse than chemotherapy. But the decision should be made by the treating clinician only as he is evaluating the case. Consult an oncologist - Best Oncologist In India. Hope our answer helps you.